An Epigenetic Roadmap for Cardiomyocyte Differentiation
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte Marker Expression in Mouse Embryonic Fibroblasts by Cell-Free Cardiomyocyte Extract and Epigenetic Manipulation
Background: The regenerative capacity of the mammalian heart is quite limited. Recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. We investigated whether fibroblasts could transdifferentiate into myocardium.Methods: Mouse embryonic fibroblasts were treated with Trichostatin A (TSA) and 5-Aza-2-Deoxycytidine (5-aza-dC). The treated cells were permeabilized w...
متن کاملcardiomyocyte marker expression in mouse embryonic fibroblasts by cell-free cardiomyocyte extract and epigenetic manipulation
background: the regenerative capacity of the mammalian heart is quite limited. recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. we investigated whether fibroblasts could transdifferentiate into myocardium. methods: mouse embryonic fibroblasts were treated with trichostatin a (tsa) and 5-aza-2-deoxycytidine (5-aza-dc). the treated cells were permeabilized ...
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E pigenetic modifications, including DNA methylation, chromatin remodeling, and histone acetylation or meth-ylation, regulate gene expression either by suppressing or activating target genes. Modifications, such as DNA methylation and trimethylation of H3K9 and H3K27, are well-described characteristics of heterochromatin, tightly packed DNA that can repress gene expression, 1,2 whereas trimethy...
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Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed. Comparative analysis indicated strict conservation of both gene organisation and coding sequence of the chick, mouse, and human RhoA genes. Bioinformatics analysis of the derived promo...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.301134